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Polyethylene Glycol – Functionalized Titanium Dioxide Nanoparticles for Extended Release of Diethylenetriaminepentaacetic Acid into Lung Fluid to Enhance the Decorporation of Radioactive Actinides

Research Article

Polyethylene Glycol – Functionalized Titanium Dioxide Nanoparticles for Extended Release of Diethylenetriaminepentaacetic Acid into Lung Fluid to Enhance the Decorporation of Radioactive Actinides 


Almalki M1, Lai EPC1*, Ko R2 and Li CS2

1Department of Chemistry, Carleton University, Canada
2Radiation Protection Bureau, Health Canada, Canada

*Corresponding author: Edward PC Lai, Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada, Tel: +1 61352026003835; Email: edward.lai@carleton.ca

Received: May 06, 2017; Accepted: August 21, 2017; Published: September 05, 2017

Abstract

Titanium dioxide (TiO2) nanoparticles have been used widely as a nanocarrier in drug delivery systems due to their high delivery efficiency and controlled release of therapeutic drugs. Diethylenetriaminepentaacetic Acid (DTPA) is an attractive decorporationagent that can enhance the excretion of radioactive actinides such as uranium, plutonium and americium after a radiological incident. However, DTPA is excreted in a short period of time after administration. In this project, biocompatible Polyethylene Glycol (PEG) functionalized TiO2 nanoparticles was used to load DTPA to increase its residence time in the human body. The prepared DTPA-loaded PEG-functionalized TiO2 nanoparticles were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy and dynamic light scattering. The prolonged retention of DTPA from PEG-functionalized TiO2 nanoparticles were also evaluated via dialysis experiments. Liquid chromatography-mass spectrometry analysis of the dialysates showed an extended release of DTPA into simulated lung fluid.This approach was used for the first time to sustain the release of DTPA in an in vitro study.


Keywords

Decorporation agent; Dialysis; DTPA; In vitro release; Simulated lung fluid; Titanium dioxide nanoparticles

Citation: Almalki M, Lai EPC, Ko R, Li CS (2017) Polyethylene Glycol – Functionalized Titanium Dioxide Nanoparticles for Extended Release of Diethylenetriaminepentaacetic Acid into Lung Fluid to Enhance the Decorporation of Radioactive Actinides. J Nanosci Nanomed Nanobio 1: 002.

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