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Stem Cells: Current Therapeutic Strategies for Alzheimer’s Disease

Review Article

ISSN: 2565-571X

Stem Cells: Current Therapeutic Strategies for Alzheimer’s Disease 


Ankur P Patel, Seetha Tamma*, Grishma N Joshi and Rupali P Ugile

Department of Biomedical Sciences, Long Island University, New York, USA

*Corresponding author: Ankur P Patel, Department of Biomedical Sciences, Specialization in Immunology, C W Post College, Long Island University, New York, USA, Tel: +1 2127489329; Email: ankur.patel2@my.liu.edu

Received: August 02, 2016; Accepted: January 20, 2017; Published: February 03, 2017

Abstract

The loss of neuronal cells in the central nervous system may happen in numerous neurodegenerative illnesses. Alzheimer’s Disease (AD) is an intricate, irreversible, dynamic neurodegenerative sickness. It is the main source of age-related dementia, influencing roughly 5.3 million individuals in the United States alone AD is a common senile disease in people over 65 years of age, bringing on impairment described by decrease in memory, failure to learn and do every day exercises and intellectual weakness and influences the personal satisfaction of patients. Pathologic characteristics of AD are an irregular development of specific proteins called Beta-amyloid “plaques” and Tau “Tangles” in the brain. Current treatments against AD are just to relieve symptoms and palliative, not the cure and a few promising drug candidates have failed in recent clinical trials. There is consequently a critical need to enhance our comprehension for pathogenesis of this sickness, making new and creative prescient models with powerful treatments. Recent advances indicate that stem cell treatment appears to be a promising approach to deal with different illnesses, including neurodegenerative disorders. Stem cell substitution procedures have been challenging extremely treatment approach to treat AD. Stem Cell therapy may offer an effective new approach in AD treatment and furthermore, may be used as a model for other neurodegenerative diseases. Patient derived induced Pluripotent Stem Cells (iPSCs), for instance, may further our understanding of disease mechanism. In this review we will discuss the potential of stem cells and their use in treatment options to this challenging disease.

Keywords

Alzheimer’s disease; Induced pluripotent stem cells; Neurogenesis; Oxidative stress; Stem cell therapy; Transplantation

Citation: Patel AP, Tamma S, Joshi GN, Ugile RP (2017) Stem Cells: Current Therapeutic Strategies for Alzheimer’s Disease. J Cell Mol Biol 2: 007.

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