Mini review
Volume Kinetic Shocks in Surgical Practice
Ahmed N. Ghanem
Department of Medicine, Mansoura University, Egypt
*Corresponding author: Ahmed N. Ghanem, Department of Medicine, Mansoura University, Egypt, Tel: 07306321589; Email: anmghanem1@gmail.com
Received: July 16, 2020; Accepted: August 03, 2020; Published: August 10, 2020
Abstract
Volume kinetic shocks are cardiovascular shocks induced by acute substantial volume changes of the cardiovascular system in either direction by decrease or increase. A decrease in cardiovascular volume induces the long established and well-known hypovolemic/hemorrhagic shocks. Cardiovascular shocks induced by volumetric overload have recently been reported first in 2016. Volumetric overload shocks (VOS) are of two types, depending on the type of fluid inducing it: Sodium-free fluid induce type 1 (VOS 1) and sodium-based fluid induce type 2 (VOS 2).
These VOS present with cardiovascular shock or cardiopulmonary arrest in theatre and the acute respiratory distress syndrome (ARDS) later. It is iatrogenic complication of fluid therapy that is underrecognized and underestimated. VOS1 is induced by infusion of 3.5-5 liters of sodium-free fluid in one hour and is characterized with dilution hyponatraemia. VOS2 may complicate VOS 1 or may occur de novo complicating sodium-based fluid therapy during resuscitation of shock, acutely ill patients, and prolonged surgery. It has no obvious serological markers or none. Many errors and misconceptions mislead physicians into giving too much fluid for resuscitation of shock due to faulty rules on fluid therapy dictated by the wrong Starling’s law. The correct replacement for this law is the hydrodynamic of the porous orifice G tube. Discovery of VOS has resolved the puzzles of the transurethral resection of the prostate (TURP) Syndrome, hyponatraemia (HN) and the acute respiratory distress syndrome(ARDS) or the multiple organ dysfunction syndrome (MODS).
Keywords
Acute respiratory distress syndrome (ARDS); Capillary physiology; Hyponatraemia; Shock; Starling’s law; Transurethral resection of the prostate (TURP) syndrome; Volumetric overload Socks
Introduction
Volume kinetic (VK) shocks are cardiovascular shocks induced by acute substantial volume changes of the cardiovascular system in either direction by decrease or increase. A decrease in cardiovascular volume induces the long established and well-known hypovolemic/hemorrhagic shocks. Cardiovascular shocks induced by volumetric overload (VO) have been recently reported [1-4], first in 2016.Volumetric overload shocks (VOS) are of two types, depending on the type of fluid inducing it: Sodium-free fluid induce type one (VOS1) and sodium-based fluid induce type 2 (VOS 2). Both types of VOS complicate fluid therapy in clinical practice affecting mostly surgical patients during the resuscitation of shock, acutely ill patients and during prolonged major surgery.
There are many errors and misconceptions on fluid therapy [5,6] that mislead physicians [7] into giving too much fluid during shock resuscitation. These errors are dictated by faulty rules on fluid therapy induced by the wrong Starling’s law [8-10] that dictates these faulty rules. This transfers the shock being treated such as hemorrhagic or septic shock into VOS, seamlessly and un-noticed when excessive crystalloids and/or colloids fluids are infused. Examples of VOS 1 are the condition known in urology as the transurethral resection of the prostate (TURP) syndrome [11] or hyponatremic shock [12].
The TURP syndrome is induced by massive fluid gain of 3.5-5 liters mostly of 1.5% Glycine and/or 5%Glucose infusion in one hour. Hyponatremic shock is induced by excessive 5%Glucose infusion during prolonged major surgery in women. The TURP syndrome occur when large volume of the irrigating 1.5% Glycine is absorbed during the one-hour TURP surgery. This VOS 1 occurs during or immediately after surgery presenting to anesthetists and surgeons and is usually mistaken for one of the known shocks of hemorrhagic or septic and gets wrongly treated by further volume expansion using crystalloids and/or colloids with disastrous or lethal outcome. By next morning after surgery it presents to physicians with hyponatremic encephalopathy manifesting with coma, convulsion and paralysis [13]. Other manifestations of the multiple organ dysfunction syndrome (MODS) [14-15], also known as the acute respiratory distress syndrome (ARDS), do occur, but one system may predominate (Table 1).
Also occurs the excessive bleeding at the surgical site and Leucocytosis also occurred in the absence of sepsis and septic shock. Although sepsis and septic shock do certainly cause ARDS, it may perhaps be as innocent as the Wolf in Josef story in most situations.
VOS 2 may complicate the therapy of VOS 1 when excessive crystalloids and colloids are infused. It may complicate other types of known shocks when excessive crystalloids and/or colloids fluids are infused. It is hard to recognize in this setting and impossible to differentiate from the shock being treated as it has little or no serological marker like hyponatraemia of VOS 1. It presents later with ARDS or MODS thus VOS causing ARDS has been established beyond any doubt [14,15]. Although fluid retention in ARDS patients has recently been reported in prospective huge multi-center trials in surviving patients ranging from 3-10 liters [16,17], and in mortality cases ranging from 12-14 liters [18], it has never before been incriminated in the patho-aetiology of ARDS till recently [14-15].
Professor Hahn from Sweden studied VK in healthy volunteers and patients [19-20]. He concluded that: “Guidelines for fluid therapy rarely take into account that adverse effects occur in a dose-dependent fashion. Adverse effects of crystalloid fluids are related to their preferential distribution to the interstitial of the subcutis, the gut, and the lungs. The gastrointestinal recovery time is prolonged by 2 days when more than 2 liters is administered. Infusion of 6-7 liters during open abdominal surgery results in poor wound healing, pulmonary oedema, and pneumonia. There is also a risk of fatal postoperative pulmonary oedema that might develop several days after the surgery. Even larger amounts cause organ dysfunction by breaking up the interstitial matrix and allowing the formation of lacunae of fluid in the skin and central organs, such as the heart. For both crystalloid and colloid fluids, coagulation becomes impaired when the induced hemodilution has reached 40%. Coagulopathy is aggravated by co-existing hypothermia. Although oedema can occur from both crystalloid and colloid fluids, these differ in pathophysiology.”
Other authors also found a significant effect of crystalloids overload on mortality as they did the research during the first 24-48 hours from hospital admission. I have found only one prospective study on adults’ trauma patients by Jones et al (2016) [21], and one prospective paediatrics study by Coons et al (2018) [22] and a remarkable review article by Schrier. Reported in 2010 [23], that incriminate saline overload and recommend judicious use of fluid infusion during resuscitation of shock and trauma. In patients of these adult and paediatrics trauma trials there is no sepsis involved and both were done over a period of 24 and 48 hours, respectively. Both articles detected a significant relationship of VO with morbidity and mortality of ARDS.
Jones et al. [21] reported in conclusion: “Large-volume crystalloid resuscitation is associated with increased mortality and longer time ventilated. Based on this data, we recommend judicious use of crystalloids in the resuscitation of trauma patients.”The conclusion by Coons et al [22] was: “Early administration of high volumes of crystalloid fluid greater than 60 ml/kg/day significantly correlates with pulmonary complications, days NPO, and hospital length of stay. These results span the first 48 h of a patient’s hospital stay and should encourage surgical care providers to exercise judicious use of crystalloid fluid administration in the trauma bay, ICU, and floor”.
There are currently substantial physics [8,9] and physiological [10] evidence that Starling’s law is wrong. It is responsible for the faulty rules on fluid therapy [5] that mislead physicians [7] into giving too much fluid during the resuscitation of shock that induce VOS causing ARDS [14,15].Other authors have found that Starling’s forces do not hold in clinical practice [24,25]. The editor of The British Journal of Anaesthesia 2012 commented on this article [25] “The classic Starling principle does not hold for fluid resuscitation in clinical setting.” I have not only proved that Starling’s law is wrong on both of its forces, but also have provided its correct replacement; the hydrodynamic of the porous orifice (G) tube [8-10] (Figure 1).
Discovery of VOS has resolved the puzzles of the TURP Syndrome, hyponatraemia and ARDS: Not only the exact patho-aetiology diagnosisof these conditions were precisely identified but also a lifesaving treatment of hypertonic sodium therapy (HST) of 5% NaCl and/or 8.4% NaCo3was discovered and rejuvenated [14,15].
Conclusion
Acute, substantial volume kinetic in either direction of loss or gain causes cardiovascular shocks. Volumetric overload shocks (VOS) are newly recognized. It may present with shock or cardiopulmonary arrest in theatre and ARDS later. It is an iatrogenic complication of fluid therapy in hospitals that is under recognized and under-estimated. VOS is 2 types: VOS1 and VOS2. VOS1 is induced by 3.5-5 liters of sodium-free fluid and is characterized with dilution hyponatraemia (HN). VOS 2 may complicate VOS 1 or may occur de novo complicating sodium-based fluid therapy during the resuscitation of shock, acutely ill patients, and prolonged surgery. It has no obvious serological markers or none. Up to 10 liters of fluids are retained in surviving ARDS patients while those who die retain 12-14 liters. Many errors and misconceptions mislead physicians into giving too much fluid for resuscitation due to faulty rules on fluid therapy dictated by the wrong Starling’s law. The correct replacement for this law is the hydrodynamic of G tube. Discovery of VOS has resolved the puzzles of TURP Syndrome, HN and ARDS.
Conflict of interest
None
Funds received
None.
Acknowledgements
I thank Dr. Khaled and Dr. Salma; son and daughter of the author, for constructing (Table 1) and for assistance with editing of this article.
Figures
Shows a diagrammatic representation of the hydrodynamic of G tube based on G tubes and chamber C. This 38-years old diagrammatic representation of the hydrodynamic of G tube in chamber C is based on few photographs. The G tube is the plastic tube with narrow inlet and pores in its wall built on a scale to capillary ultra-structure of precapillary sphincter and wide inter cellular slit pores. The chamber C around it is another bigger plastic tube to form the G-C apparatus. The chamber C represents the ISF space. The diagram represents a capillary-ISF unit that should replace Starling’s law in every future physiology, medical and surgical textbooks, and added to chapters on hydrodynamics in physics textbooks. The numbers should read as follows:
- The inflow pressure pushes fluid through the orifice
- Creating fluid jet in the lumen of the G tube**.
- The fluid jet creates negative side pressure gradient causing suction maximal over the proximal part of the G tube near the inlet that sucks fluid into lumen.
- The side pressure gradient turns positive pushing fluid out of lumen over the distal part maximally near the outlet.
- Thus, the fluid around G tube inside C moves in magnetic field-like circulation (5) taking an opposite direction to lumen flow of G tube.
- The inflow pressure 1 and orifice 2 induce the negative side pressure creating the dynamic G-C circulation phenomenon that is rapid, autonomous, and efficient in moving fluid and particles out from the G tube lumen at 4, irrigating C at 5, then sucking it back again at 3,
- Maintaining net negative energy pressure inside chamber C.
**Note the shape of the fluid jet inside the G tube (Cone shaped), having a diameter of the inlet on right hand side and the diameter of the exit at left hand side (G tube diameter). I lost the photo on which the fluid jet was drawn, using tea leaves of fine and coarse sizes that runs in the center of G tube leaving the outer zone near the wall of G tube clear. This may explain the finding in real capillary of the protein-free (and erythrocyte-free) sub-endothelial zone in the Glycocalyx paradigm (Woodcock and Woodcock 2012) [25]. I also noted that fine tea leaves exit the distal pores in small amount maintaining a higher concentration in the circulatory system- akin to plasma proteins.
Tables
Cerebral | Cardiovascular | Respiratory | Renal | Hepatic & GIT |
Numbness
Tingling SBB1 COC2 Coma Convulsions PMBCI 3 |
Hypotension
Bradycardia Dysrhythmia CV Shock* Cardiac Arrest Sudden Death
|
Cyanosis.
FAM4 APO)5 RA6 Arrest CPA7 Shock lung ARDS8 |
Oliguria
Annuria8 Renal failure or AKI9 Urea ? Creatinine ?
|
Dysfunction:
Bilirubin ? SGOT ? Alkaline Phosph. GIT symptoms. DGR10 Paralytic ileus Nausea & Vomiting. |
Abbreviations: SBB1: Sudden bilateral blindness; PMBCI3: Paralysis mimicking bizarre cerebral infarctions, but is recoverable on instant use of HST of 5% NaCl and/or NaCo3, and so is coma and AKI; FAM4: Frothing around the mouth; APO5: Acute pulmonary oedema; RA6: Respiratory arrest; CPA7: Cardiopulmonary arrest; ARDS8 : Acute respiratory distress syndrome. Occurs later on ICU; AKI9 : Acute kidney injury; DGR10: Delayed gut recovery; CV Shock*: Cardiovascular shock of VOS reported here as VOS1 and VOS2; Annuria8 : That is unresponsive to diuretics but responds to HST of 5% Nacl and/or 8.4%NaCo3; AKI8: Acute kidney injury. |
References
- Ghanem AN, Ghanem SA (2016) Volumetric Overload Shocks: Why Is Starling’s Law for Capillary Interstitial Fluid Transfer Wrong? The Hydrodynamics of a Porous Orifice Tube as Alternative. Surgical Science 7: 245-249.
- Pindoria N, Ghanem SA, Ghanem KA, Ghanem AN (2017) Volumetric overload shocks in the path aetiology of the transurethral resection prostatectomy syndrome and acute dilution hyponatraemia. Integr Mol Med.
- Ghanem SA, Ghanem KA, Ghanem AN (2017) Volumetric overload shocks in the patho-aetiology of the Transurethral Resection of the Prostate (TURP) Syndrome and acute dilution hyponatraemia: The clinical evidence based on prospective clinical study of 100 consecutive TURP patients. Biomed Res Clin Prac: 2: 2-7.
- Ghanem KA, Ghanem AN (2017) Volumetric overload shocks in the patho-aetiology of the transurethral resection prostatectomy syndrome and acute dilution hyponatraemia: The clinical evidence based on 23 case series. Basic Research J Med Clin Sci 6: 2315-6864.
- Ghanem AN (2018) The Adult Respiratory Distress Syndrome: Volumetric Overload Shocks in Patho-Aetiology, Correcting Errors and Misconceptions on Fluid Therapy, Vascular and Capillary Physiology. Surg Med Open Acc J: 2.
- Ghanem AN (2019) Complication of Fluid Therapy Causing the Acute Respiratory Distress Syndrome: Facts and Comments. The Role of Volumetric Overload Shocks in Patho-aetiology. Archives of Urology 2: 21-31.
- Ghanem AN (2020) What are Misleading Physicians into giving too much Fluid During Resuscitation of Shock and Surgery that Induces ARDS and/or AKI?”. Asp Biomed Clin Case Rep: 3: 90-98.
- Ghanem AN (2001) Magnetic field-like fluid circulation of a porous orifice tube and its relevance to the capillary-interstitial fluid circulation: preliminary report. Med Hypotheses 56: 325-334.
- Ghanem KA, Ghanem AN (2017) The proof and reasons that Starling’s law for the capillary-interstitial fluid transfer is wrong, advancing the hydrodynamics of a porous orifice (G) tube as the real mechanism. Blood, Heart and Circ: 1-17.
- Ghanem KA, Ghanem AN (2017) The Physiological Proof that Starling’s Law for the Capillary-Interstitial Fluid Transfer is wrong: Advancing the Porous Orifice (G) Tube Phenomenon as Replacement. Open Acc Res Anatomy: 1.
- Ghanem AN, Ward JP (1990) Osmotic and metabolic sequelae of volumetric overload in relation to the TUR syndrome. Br J Urol 66: 71-78.
- Harrison RH, Boren JS, Robison JR (1956) Dilutional hyponatraemic shock: another concept of the transurethral prostatic resection reaction. J Urol 75: 95-110.
- Arieff AI (1986) Hyponatremia, convulsions, respiratory arrest, and permanent brain damage after elective surgery in healthy women. N Engl J Med 314:1529-1535.
- Ghanem AN (2020) The Correct Replacement for the Wrong Starling’s law is the Hydrodynamic of the Porous Orifice (G) Tube: The Complete Physics and physiological Evidence with Clinical Relevance and Significance. Cardio Open 5: 1-9.
- Ghanem AN (2020) Volumetric overload shocks cause the acute respiratory distress syndrome: The plenary evidence on patho-aetiology and therapy. Op Acc J Bio Sci & Res 1: 1-9.
- Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, et al. (2017) Early, Goal-Directed Therapy for Septic Shock – A Patient-Level Meta-Analysis. N Engl J Med 376: 2223-2234.
- Huang DT, Angus DC, Barnato A, Gunn SR, Kellum JA, et al. (2013) Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med 39: 1760-1775
- Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. The Lancet 2: 319-323.
- Hahn RG (2017) Adverse effects of crystalloid and colloid fluids. Anaesthesiology Intensive Ther 49: 303-308.
- Hahn RG (2020) REVIEW ARTICLE Understanding volume kinetics. Acta Anaesthesiol Scand 64: 570-578.
- Jones DG, Nantais J, Rezende-Neto JB, Yazdani S, Vegas P, et al. (2018) Crystalloid resuscitation in trauma patients: deleterious effect of 5L or more in the first 24h. BMC Surg 18: 93.
- Coons BE, Tam S, Rubsam J, Stylianos S, Duron V (2018) High volume crystlloid resuscitation adversely affects paediatric trauma patients. J Pediatr Surg 53: 2202-2208.
- Schrier RW (2010) Fluid administration in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol 5: 733-739.
- Alphonsus CS, Rodseth RN (2014) The endothelial glycocalyx: a review of the vascular barrier. Anaesthesia 69: 777-784.
- Woodcock TE, Woodcock TM (2012) Revised Starling equation and the glycocalyx model of trans-vascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy. Br J Anaesth 108: 384-394.
Citation: Ahmed N. Ghanem (2020) Volume Kinetic Shocks in Surgical Practice. J Emerg Med Trauma Surg Care 2: 010.
Copyright: © 2020 Ahmed N. Ghanem. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.